Abstract |
In 17 patients of genital herpes virus infections, herpes simplex virus (HSV)-specific IgA antibody responses were analyzed using an enzyme-linked immunosorbent assay (ELISA) and the absorption of sera with Streptococcus pyogenes, AW43 and AR1, which bind monomeric IgA (m- IgA) and IgG antibodies, respectively. The ratio of polymeric IgA (p- IgA) to total IgA was calculated from the formula, the p- IgA index = IgA activity after absorption/ IgA activity before absorption. In early-convalescent-phase sera from primary cases, the p- IgA indices were 0.5-0.9, whereas in recurrent or provoked cases, they were lower than 0.2. There results indicate that the p- IgA index may be useful for rapid and simple differentiation of primary from non-primary HSV infections.
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Authors | M Hashido, T Kawana, S Inouye |
Journal | Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
(Kansenshogaku Zasshi)
Vol. 66
Issue 2
Pg. 225-31
(Feb 1992)
ISSN: 0387-5911 [Print] Japan |
PMID | 1402085
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antibodies, Viral
- Immunoglobulin A
- Polymers
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Topics |
- Antibodies, Viral
(analysis)
- Enzyme-Linked Immunosorbent Assay
- Female
- Herpes Genitalis
(diagnosis)
- Humans
- Immunoglobulin A
(analysis)
- Polymers
(analysis)
- Recurrence
- Serologic Tests
(methods)
- Streptococcus pyogenes
(immunology)
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