Abstract |
The efficacy of a wide-spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N-bis(2-hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N-ethyl-N-hydroxyethylnitrosamine (1500 mg/kg body weight, i.g., in distilled water, twice in week 2) and 3,2'-dimethyl-4-aminobiphenyl (75 mg/kg body weight, s.c., in corn oil, twice in week 3) for wide-spectrum initiation of target organs and then given one of 10 test chemicals, comprising 6 hepatocarcinogens and 4 non-hepatocarcinogens, for 12 weeks. All 10 chemicals exerted modifying effects in their respective target organs. Enhancing influence could be detected in the liver and urinary bladder with 2-acetylaminofluorene, ethionine, and 3'-methyl-4-dimethylaminoazobenzene; in the liver and thyroid with 4,4'-diaminodiphenylmethane and phenobarbital; in the esophagus and urinary bladder with N-butyl-N-(4-hydroxybutyl) nitrosamine; in the forestomach and urinary bladder with butylated hydroxyanisole; in the liver with 7,12-dimethylbenz[a] anthracene and in the liver and lung with 3-methylcholanthrene. Inhibitory effects on development of glutathione S-transferase placental form-positive liver cell foci were observed with clofibrate. The results indicate that the present model can be reliably utilized as a whole body medium-term bioassay system for assessment of environmental cancer modifiers.
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Authors | S Uwagawa, H Tsuda, K Ozaki, S Takahashi, S Yamaguchi, M Mutai, T Aoki, N Ito |
Journal | Japanese journal of cancer research : Gann
(Jpn J Cancer Res)
Vol. 83
Issue 8
Pg. 812-20
(Aug 1992)
ISSN: 0910-5050 [Print] Japan |
PMID | 1399818
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Body Weight
(drug effects)
- Carcinogenicity Tests
- Carcinogens
(toxicity)
- Drinking Behavior
(drug effects)
- Esophageal Neoplasms
(chemically induced, pathology)
- Feeding Behavior
(drug effects)
- Liver Neoplasms
(chemically induced, pathology)
- Liver Neoplasms, Experimental
(chemically induced)
- Lung Neoplasms
(chemically induced, pathology)
- Male
- Neoplasms, Experimental
(chemically induced, pathology)
- Organ Specificity
- Rats
- Rats, Inbred F344
- Urinary Bladder Neoplasms
(chemically induced, pathology)
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