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Modifying effects of various chemicals on tumor development in a rat wide-spectrum organ carcinogenesis model.

Abstract
The efficacy of a wide-spectrum organ carcinogenesis model for detection of modification potential of exogenous agents was investigated in F344 male rats. Groups of animals were sequentially injected with N-bis(2-hydroxypropyl)nitrosamine (1000 mg/kg body weight, i.p., in saline, twice in week 1), N-ethyl-N-hydroxyethylnitrosamine (1500 mg/kg body weight, i.g., in distilled water, twice in week 2) and 3,2'-dimethyl-4-aminobiphenyl (75 mg/kg body weight, s.c., in corn oil, twice in week 3) for wide-spectrum initiation of target organs and then given one of 10 test chemicals, comprising 6 hepatocarcinogens and 4 non-hepatocarcinogens, for 12 weeks. All 10 chemicals exerted modifying effects in their respective target organs. Enhancing influence could be detected in the liver and urinary bladder with 2-acetylaminofluorene, ethionine, and 3'-methyl-4-dimethylaminoazobenzene; in the liver and thyroid with 4,4'-diaminodiphenylmethane and phenobarbital; in the esophagus and urinary bladder with N-butyl-N-(4-hydroxybutyl)nitrosamine; in the forestomach and urinary bladder with butylated hydroxyanisole; in the liver with 7,12-dimethylbenz[a]anthracene and in the liver and lung with 3-methylcholanthrene. Inhibitory effects on development of glutathione S-transferase placental form-positive liver cell foci were observed with clofibrate. The results indicate that the present model can be reliably utilized as a whole body medium-term bioassay system for assessment of environmental cancer modifiers.
AuthorsS Uwagawa, H Tsuda, K Ozaki, S Takahashi, S Yamaguchi, M Mutai, T Aoki, N Ito
JournalJapanese journal of cancer research : Gann (Jpn J Cancer Res) Vol. 83 Issue 8 Pg. 812-20 (Aug 1992) ISSN: 0910-5050 [Print] Japan
PMID1399818 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Carcinogens
Topics
  • Animals
  • Body Weight (drug effects)
  • Carcinogenicity Tests
  • Carcinogens (toxicity)
  • Drinking Behavior (drug effects)
  • Esophageal Neoplasms (chemically induced, pathology)
  • Feeding Behavior (drug effects)
  • Liver Neoplasms (chemically induced, pathology)
  • Liver Neoplasms, Experimental (chemically induced)
  • Lung Neoplasms (chemically induced, pathology)
  • Male
  • Neoplasms, Experimental (chemically induced, pathology)
  • Organ Specificity
  • Rats
  • Rats, Inbred F344
  • Urinary Bladder Neoplasms (chemically induced, pathology)

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