Isometachromin, a new cytotoxic sesquiterpenoid from a deep water sponge of the family Spongiidae.

Abstract

Isometachromin (1), a new sesquiterpene-quinone that is related structurally to metachromin C (2), and the known compounds ilimaquinone (3) and 5-epi-ilimaquinone (4), were isolated from a deep water sponge in the family Spongiidae; the structure of isometachromin was elucidated by spectral methods. Isometachromin exhibits in vitro cytotoxicity against the human lung cancer cell line A549 (IC50 = 2.6 micrograms/ml), but not against P388 murine leukemia (IC 50 > or equal to 10 micrograms/ml) and also exhibits antimicrobial activity.

• Authors: O J McConnell, R Longley, M Gunasekera
• Journal: Experientia (Experientia) Vol. 48 Issue 9 Pg. 891-2 (Sep 15 1992) ISSN: 0014-4754 [Print] Switzerland
• PMID: 1397187 (Publication Type: Journal Article)

Chemical References

• Cytotoxins
• Sesquiterpenes
• isometachromin

Topics

• Animals
• Cytotoxins (chemistry, isolation & purification)
• Magnetic Resonance Spectroscopy
• Porifera (chemistry)
• Sesquiterpenes (chemistry, isolation & purification)