[Fusarin C induced esophageal and forestomach carcinoma in mice and rats].

Abstract

Fusarium moniliforme, a fungus of established carcinogenic potential, is one of the most common fungal contaminants of maize, millet and other grains in Linxian, China, a high-risk county for human esophageal cancer. Fusarin C, a major product of F. moniliforme grown on corn in the laboratory, is mutagenic in Salmonella tester strains and in V79 cells. Fusarin C treated rat esophageal epithelial cell line showed several characteristics of malignant transformations including the growth in nude mice. The present work demonstrated that Fusarin C can induce esophageal and forestomach carcinoma in DBA mice and Wistar rats thus further substantiating the carcinogenicity of this mycotoxin.

• Authors: M X Li
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 14 Issue 1 Pg. 27-9 (Jan 1992) ISSN: 0253-3766 [Print] China
• PMID: 1396042 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Polyenes
• fusarin C

Topics

• Animals
• Carcinoma, Squamous Cell (chemically induced)
• Esophageal Neoplasms (chemically induced)
• Female
• Hyperplasia (chemically induced)
• Mice
• Mice, Inbred DBA
• Papilloma (chemically induced)
• Polyenes
• Precancerous Conditions (chemically induced)
• Rats
• Rats, Inbred Strains
• Stomach Neoplasms (chemically induced)