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Anisomycin and cycloheximide protect cerebellar neurons in culture from anoxia.

Abstract
Protein synthesis inhibitors have recently been shown to protect from ischemia-induced neuronal death in the rat hippocampus in vivo. In an attempt to further investigate the mechanism of neuronal death resulting from anoxia, cerebellar neurons grown in culture were exposed to an anoxic atmosphere in the presence of protein synthesis inhibitors. Anisomycin and cycloheximide (100 micrograms/ml) offered, respectively, a 97 +/- 4% and 26 +/- 13% protection against anoxia-induced neuronal death.
AuthorsF Dessi, C Charriaut-Marlangue, Y Ben-Ari
JournalBrain research (Brain Res) Vol. 581 Issue 2 Pg. 323-6 (May 29 1992) ISSN: 0006-8993 [Print] Netherlands
PMID1393538 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anisomycin
  • Dizocilpine Maleate
  • Cycloheximide
Topics
  • Animals
  • Anisomycin (pharmacology)
  • Cell Death (drug effects)
  • Cell Hypoxia (drug effects)
  • Cells, Cultured
  • Cerebellum (cytology)
  • Cycloheximide (pharmacology)
  • Dizocilpine Maleate (pharmacology)
  • Neurons (cytology, drug effects)
  • Rats

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