Abstract |
Since it was first described mixed connective tissue disease ( MCTD) has been the subject of much debate. In particular the question of whether it is a truly distinctive disease entity has been challenged. It seems clear that the original description of MCTD as a mild disorder, rarely affecting the lungs or kidneys and requiring small doses of corticosteroids only, is no longer tenable. In this review a historical analysis of the clinical and serological features is presented. It is suggested that the concept of MCTD as a distinct disease entity is better replaced by the term 'undifferentiated autoimmune rheumatic/connective tissue disorder'. Many of these patients will later 'convert' into scleroderma or lupus; some will remain undifferentiated.
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Authors | C Black, D A Isenberg |
Journal | British journal of rheumatology
(Br J Rheumatol)
Vol. 31
Issue 10
Pg. 695-700
(Oct 1992)
ISSN: 0263-7103 [Print] England |
PMID | 1393377
(Publication Type: Journal Article, Review)
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Chemical References |
- Autoantibodies
- Autoantigens
- Ribonucleoprotein, U1 Small Nuclear
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Topics |
- Autoantibodies
(metabolism)
- Autoantigens
(immunology)
- Autoimmune Diseases
(epidemiology, immunology, pathology)
- Humans
- Lupus Erythematosus, Systemic
(pathology)
- Mixed Connective Tissue Disease
(epidemiology, immunology, pathology)
- Prevalence
- Prognosis
- Ribonucleoprotein, U1 Small Nuclear
(immunology)
- Scleroderma, Systemic
(pathology)
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