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Mixed connective tissue disease--goodbye to all that.

Abstract
Since it was first described mixed connective tissue disease (MCTD) has been the subject of much debate. In particular the question of whether it is a truly distinctive disease entity has been challenged. It seems clear that the original description of MCTD as a mild disorder, rarely affecting the lungs or kidneys and requiring small doses of corticosteroids only, is no longer tenable. In this review a historical analysis of the clinical and serological features is presented. It is suggested that the concept of MCTD as a distinct disease entity is better replaced by the term 'undifferentiated autoimmune rheumatic/connective tissue disorder'. Many of these patients will later 'convert' into scleroderma or lupus; some will remain undifferentiated.
AuthorsC Black, D A Isenberg
JournalBritish journal of rheumatology (Br J Rheumatol) Vol. 31 Issue 10 Pg. 695-700 (Oct 1992) ISSN: 0263-7103 [Print] England
PMID1393377 (Publication Type: Journal Article, Review)
Chemical References
  • Autoantibodies
  • Autoantigens
  • Ribonucleoprotein, U1 Small Nuclear
Topics
  • Autoantibodies (metabolism)
  • Autoantigens (immunology)
  • Autoimmune Diseases (epidemiology, immunology, pathology)
  • Humans
  • Lupus Erythematosus, Systemic (pathology)
  • Mixed Connective Tissue Disease (epidemiology, immunology, pathology)
  • Prevalence
  • Prognosis
  • Ribonucleoprotein, U1 Small Nuclear (immunology)
  • Scleroderma, Systemic (pathology)

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