DNA analysis of two patients with a non-fluorescent Y chromosome.

Abstract

Results of DNA study on two patients of gonadal dysgenesis with a 45,X/46,X,Ynf (non-fluorescent Y chromosome) karyotype are described. In one patient who developed gonadoblastoma, all 12 loci on the non-fluorescent part of Yq were detected. Another patient did not have gonadoblastoma at 20 years, and only the proximal 6 loci out of 12 were detected.

• Authors: T Sekine, K Fukutani, T Motegi, H Hayakawa, T Tamura, S Nagafuchi, Y Nakahori, Y Nakagome
• Journal: The Japanese journal of human genetics (Jpn J Hum Genet) Vol. 37 Issue 2 Pg. 157-62 (Jun 1992) ISSN: 0916-8478 [Print] Japan
• PMID: 1391971 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA Probes

Topics

• Adult
• Child
• Chromosome Banding
• DNA Probes
• Dysgerminoma (genetics)
• Female
• Fluorescence
• Genital Neoplasms, Female (genetics)
• Gonadal Dysgenesis (genetics)
• Humans
• Karyotyping
• Y Chromosome