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Quantification of n-alkanes in stratum corneum in the hereditary ichthyoses.

Abstract
Chromatographic assay of n-alkanes in skin showed detectable levels in normal controls and in patients with various forms of hereditary ichthyosis. Raised n-alkanes were found in some, but not all, patients with non-bullous and bullous ichthyosiform erythroderma and in individual patients with lamellar ichthyosis, ichthyosis vulgaris and Netherton's syndrome. The finding of elevated scale n-alkanes is neither consistent in ichthyosis, nor specific to any one type of ichthyosis, and n-alkane assay is not helpful in distinguishing one type of hereditary ichthyosis from another. The source of n-alkanes in ichthyotic scale and their role, if any, in the pathogenesis of ichthyosis remain obscure.
AuthorsM R Judge, N Morse-Fisher, M Manku, J I Harper
JournalThe British journal of dermatology (Br J Dermatol) Vol. 127 Issue 2 Pg. 91-6 (Aug 1992) ISSN: 0007-0963 [Print] England
PMID1390160 (Publication Type: Journal Article)
Chemical References
  • Alkanes
  • Emollients
Topics
  • Adolescent
  • Adult
  • Aged
  • Alkanes (analysis)
  • Child
  • Child, Preschool
  • Chromatography, Gas
  • Chromatography, Thin Layer
  • Emollients (therapeutic use)
  • Female
  • Humans
  • Ichthyosiform Erythroderma, Congenital
  • Ichthyosis (drug therapy, genetics)
  • Ichthyosis, X-Linked
  • Infant
  • Male
  • Sjogren-Larsson Syndrome
  • Skin (chemistry)

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