Types I and III procollagen extension peptides in serum respond to fracture in humans.

Abstract

Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.

• Authors: S Joerring, L T Jensen, G R Andersen, J S Johansen
• Journal: Archives of orthopaedic and trauma surgery (Arch Orthop Trauma Surg) Vol. 111 Issue 5 Pg. 265-7 ( 1992) ISSN: 0936-8051 [Print] Germany
• PMID: 1389778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Peptide Fragments
• Procollagen
• procollagen Type III-N-terminal peptide
• procollagen type I carboxy terminal peptide
• Osteocalcin

Topics

• Adult
• Aged
• Aged, 80 and over
• Colles' Fracture (blood, therapy)
• Female
• Humans
• Male
• Middle Aged
• Osteocalcin (blood)
• Peptide Fragments (blood)
• Procollagen (blood)