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Efficacy of intravenous magnesium in acute myocardial infarction in reducing arrhythmias and mortality. Meta-analysis of magnesium in acute myocardial infarction.

AbstractBACKGROUND:
To ascertain the effect of the intravenous administration of magnesium in acute myocardial infarction on the frequency of arrhythmias and mortality, a meta-analysis of randomized controlled trials was performed.
METHODS AND RESULTS:
The study included 930 patients with acute myocardial infarction admitted to primary referral hospitals. Administration of magnesium in acute myocardial infarction was associated with a 49% reduction in ventricular tachycardia and fibrillation. The incidence of cardiac arrest was reduced by 58%. The frequency of supraventricular tachycardias was also lower. Overall, there was a 54% reduction in mortality.
CONCLUSIONS:
Intravenous magnesium is a safe and effective method of reducing the frequency of arrhythmias and mortality in acute myocardial infarction.
AuthorsS M Horner
JournalCirculation (Circulation) Vol. 86 Issue 3 Pg. 774-9 (Sep 1992) ISSN: 0009-7322 [Print] United States
PMID1387591 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
Chemical References
  • Magnesium
Topics
  • Acute Disease
  • Arrhythmias, Cardiac (prevention & control)
  • Humans
  • Incidence
  • Injections, Intravenous
  • Magnesium (therapeutic use)
  • Meta-Analysis as Topic
  • Myocardial Infarction (complications, drug therapy, mortality)
  • Randomized Controlled Trials as Topic
  • Survival Analysis

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