HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Improved heart failure protection by FK664, a novel positive inotropic agent, in dog heart-lung preparations.

Abstract
The effects of FK664, a novel positive inotropic agent, and enoximone on pentobarbital-induced heart failure were compared in dog heart-lung preparations. Both FK664 and enoximone improved the cardiac function curve in a dose-dependent manner and restored it to the control level at drug concentrations of 1 microgram/ml and 10 micrograms/ml, respectively. Therefore, the cardiotonic potency of FK664 appears to be 10 times that of enoximone. These agents were almost equal in force-rate separation of cardiac effect. Neither of the agents produced arrhythmia at any dose tested. These results suggest that FK664 may be a potent cardiotonic agent for the treatment of heart failure.
AuthorsY Sudo, M Takai, K Esumi
JournalLife sciences (Life Sci) Vol. 51 Issue 6 Pg. PL41-6 ( 1992) ISSN: 0024-3205 [Print] Netherlands
PMID1386131 (Publication Type: Journal Article)
Chemical References
  • Cardiotonic Agents
  • Imidazoles
  • Pyrimidinones
  • FK 664
  • Enoximone
Topics
  • Animals
  • Cardiotonic Agents (therapeutic use)
  • Disease Models, Animal
  • Dogs
  • Dose-Response Relationship, Drug
  • Enoximone
  • Extracorporeal Circulation
  • Heart (drug effects, physiology)
  • Heart Failure (chemically induced, physiopathology, prevention & control)
  • Imidazoles (therapeutic use)
  • Lung (drug effects, physiology)
  • Pyrimidinones (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: