Abstract | BACKGROUND: The authors originally demonstrated the tissue-specific expression of the rab3A gene in the mouse brain. In the current study, they analyze the activity of this gene in fresh human tumors associated with neuronal phenotype compared with normal and malignant cells from other origins. METHODS: The authors studied the transcription levels of the rab3A gene by Northern blot in 81 fresh tumors. RESULTS: CONCLUSIONS: These results suggest a specific restriction pattern to human cells derived from the neural tube and neural crests. The GTP/ GDP-binding rab3A protein may be a useful differentiation marker of neuro-endocrine cells in the characterization of undifferentiated neoplasms.
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Authors | S Culine, M F Rousseau-Merck, N Honoré, C Nezelof, B Olofsson |
Journal | Cancer
(Cancer)
Vol. 70
Issue 10
Pg. 2552-6
(Nov 15 1992)
ISSN: 0008-543X [Print] United States |
PMID | 1384950
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Nerve Tissue Proteins
- RNA, Neoplasm
- RNA
- rab3 GTP-Binding Proteins
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Topics |
- Biomarkers, Tumor
- Gene Expression
- Genes, ras
- Humans
- Neoplasms
(chemistry, genetics)
- Nerve Tissue Proteins
(analysis)
- Neurosecretory Systems
(chemistry, cytology)
- RNA
(isolation & purification)
- RNA, Neoplasm
(isolation & purification)
- rab3 GTP-Binding Proteins
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