Abstract |
Previous observations have shown that oral administration of 5-hydroxytryptophan (5-HTP) without dietary prescriptions causes anorexia, decreased food intake, and weight loss in obese subjects. To confirm these data over a longer period of observation and to verify whether adherence to dietary restriction could be improved by 5-HTP, 20 obese patients were randomly assigned to receive either 5-HTP (900 mg/d) or a placebo. The study was double-blinded and was for two consecutive 6-wk periods. No diet was prescribed during the first period, a 5040-kJ/d diet was recommended for the second. Significant weight loss was observed in 5-HTP-treated patients during both periods. A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the good tolerance observed suggest that 5-HTP may be safely used to treat obesity.
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Authors | C Cangiano, F Ceci, A Cascino, M Del Ben, A Laviano, M Muscaritoli, F Antonucci, F Rossi-Fanelli |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 56
Issue 5
Pg. 863-7
(Nov 1992)
ISSN: 0002-9165 [Print] United States |
PMID | 1384305
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dietary Carbohydrates
- Dietary Proteins
- Hydroxyindoleacetic Acid
- 5-Hydroxytryptophan
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Topics |
- 5-Hydroxytryptophan
(therapeutic use)
- Adult
- Dietary Carbohydrates
(administration & dosage)
- Dietary Proteins
(administration & dosage)
- Energy Intake
- Female
- Humans
- Hydroxyindoleacetic Acid
(urine)
- Hyperphagia
(drug therapy)
- Obesity
(diet therapy, drug therapy)
- Weight Loss
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