Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: confirmation of trisomy 7 in uncultured cells.

Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short-term cultures of 1 PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3-15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha-satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.
AuthorsJ A Fletcher, C Henkle, L Atkins, A E Rosenberg, C C Morton
JournalGenes, chromosomes & cancer (Genes Chromosomes Cancer) Vol. 4 Issue 3 Pg. 264-6 (Apr 1992) ISSN: 1045-2257 [Print] UNITED STATES
PMID1382569 (Publication Type: Case Reports, Journal Article, Research Support, U.S. Gov't, P.H.S.)
  • Chromosomes, Human, Pair 5
  • Chromosomes, Human, Pair 7
  • Culture Techniques
  • Female
  • Humans
  • Middle Aged
  • Mosaicism
  • Nucleic Acid Hybridization
  • Synovitis, Pigmented Villonodular (genetics)
  • Trisomy

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