[Papillary adenocarcinoma of the prostate with good response to antiandrogen therapy and delayed radiotherapy: a case report].

Abstract

A 76-year-old man complained of initial hematuria and dysuria. Right lobe of the prostate was elastic soft, enlarged and hypoechoic. The serum levels of PA and gamma-Sm were abnormally high. Prostatic biopsy showed papillary adenocarcinoma which was stained by prostatic specific antigen (PA). The cancer was clinically diagnosed as stage C. Antiandrogen therapy was performed. After three months, the prostatic tumor markers decreased to the normal range and the tumor reduced in size without any findings of metastasis on CT scan. Because prostatic biopsy showed viable cancer cells, radiotherapy was added. After six months, the tumor reduced in size without any signs of metastasis on CT scan and prostatic biopsy revealed no viable cancer cells or elevation of the tumor markers. The positive staining for PA and the good response to antiandrogen therapy in our case support the view that papillary adenocarcinoma of the prostate is only a morphologic variant of ordinary prostatic carcinoma (acinous adenocarcinoma).

• Authors: K Ishizu, M Konishi, K Joko, H Takihara, J Sakatoku, K Tanaka
• Journal: Hinyokika kiyo. Acta urologica Japonica (Hinyokika Kiyo) Vol. 38 Issue 3 Pg. 343-6 (Mar 1992) ISSN: 0018-1994 [Print] Japan
• PMID: 1381864 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Androgen Antagonists
• Chlormadinone Acetate
• Diethylstilbestrol

Topics

• Adenocarcinoma, Papillary (drug therapy, radiotherapy, therapy)
• Aged
• Androgen Antagonists (therapeutic use)
• Chlormadinone Acetate (therapeutic use)
• Combined Modality Therapy
• Diethylstilbestrol (therapeutic use)
• Humans
• Male
• Prostatic Neoplasms (drug therapy, radiotherapy, therapy)
• Remission Induction