Abstract |
We studied the long-term outcome of patients with chronic hepatitis B virus (HBV) infection who responded to interferon (IFN) therapy. Between 1983 and 1988, 120 patients were included in 5 different protocols; 94 patients were treated with IFN and 26 were controls. Loss of serum HBV- DNA was considered a partial response and occurred in 34 of the treated patients and in 10 of the controls. Only the partial-response patients were followed up for 14-64 months (mean 46 months). HBeAg disappeared in 32/34 of the partial-response treated patients and in 9/10 of the controls. During the follow-up period, 6/34 (18%) treated patients and 1/10 controls suffered a reactivation of the disease with reappearance of HBV- DNA. Only 8/34 (23%) treated patients and 1/10 of the controls lost HBsAg; no statistical differences were observed in baseline characteristics between HBsAg-negative patients and patients who remained HBsAg-positive. Of eight HBsAg-negative treated patients, four were serum HBV- DNA-negative upon polymerase chain reaction and thus formed the HBsAg-negative control cases. Although the frequency of HBsAg loss in treated patients is relatively low, the improvement in liver disease obtained from IFN therapy is sustained over a long period.
|
Authors | V Carreño, I Castillo, J Molina, J C Porres, J Bartolomé |
Journal | Journal of hepatology
(J Hepatol)
Vol. 15
Issue 1-2
Pg. 102-6
(May 1992)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 1380526
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- DNA, Viral
- Hepatitis B Surface Antigens
- Hepatitis B e Antigens
- Interferons
|
Topics |
- Adolescent
- Adult
- Carrier State
(blood, drug therapy, immunology)
- DNA, Viral
(analysis, genetics)
- Female
- Follow-Up Studies
- Hepatitis B
(blood, drug therapy, immunology)
- Hepatitis B Surface Antigens
(analysis)
- Hepatitis B e Antigens
(analysis)
- Hepatitis B virus
(genetics, immunology)
- Humans
- Interferons
(therapeutic use)
- Male
- Middle Aged
- Polymerase Chain Reaction
- Radioimmunoassay
- Time Factors
|