The effects of intracisternal sarin and pyridine-2-aldoxime methyl methanesulphonate in anesthetized dogs.

Abstract

Dogs poisoned by the anticholinesterase sarin could be saved by intravenous administration of atropine sulphate together with a suitable oxime. The central effects of intracisternal sarin were respiratory paralysis and vasomotor stimulation. The problem arose as to whether the oxime, being a quaternary nitrogen compound, could enter the brain from the blood, and could have a central action on the paralysed respiration. The methyl methanesulphonate of pyridine-2-aldoxime administered intracisternally, after sarin poisoning by the same route, was ineffective; atropine, given intravenously, was effective. The central and peripheral effects of sarin were thus reversed by the atropine-oxime therapy, the central effects by atropine, the peripheral by the oxime.

• Authors: R V BROWN
• Journal: British journal of pharmacology and chemotherapy (Br J Pharmacol Chemother) Vol. 15 Pg. 170-4 (Mar 1960) ISSN: 0366-0826 [Print] England
• PMID: 13805033 (Publication Type: Journal Article)

Chemical References

• Cholinesterase Inhibitors
• Hydroxylamines
• Oximes
• Phosphates
• Pyridines
• Atropine
• pyridine-2-aldoxime
• Methyl Methanesulfonate
• Sarin

Topics

• Animals
• Atropine
• Cholinesterase Inhibitors
• Dogs
• Hydroxylamines (pharmacology)
• Methyl Methanesulfonate
• Oximes
• Phosphates (toxicity)
• Pyridines (pharmacology)
• Sarin