Alloimmune thrombocytopenia: in utero treatment by high doses of intravenous gamma globulins.

Abstract

The authors report successful in utero treatment by high doses of intravenous gamma globulins in a case of neonatal alloimmune thrombocytopenia. Early diagnosis allows an appropriate management: fetal blood sampling as early as 20 weeks of gestation; in case of fetal thrombocytopenia, treatment by intravenous gamma globulin (1.0 g/kg/b.w.) each week during 8 weeks or more; ultrasound screening of in utero hemorrhage, particularly intracranial hemorrhage; fetal blood sampling before delivery at term and in utero transfusion of platelet antigen negative in case of persistence of fetal thrombocytopenia.

• Authors: P Poulain, C Kaplan, C Leberre, J Milon, C Bergeron, J Y Grall
• Journal: Fetal diagnosis and therapy (Fetal Diagn Ther) Vol. 7 Issue 2 Pg. 144-6 ( 1992) ISSN: 1015-3837 [Print] Switzerland
• PMID: 1380248 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, Human Platelet
• ITGB3 protein, human
• Integrin beta3
• gamma-Globulins

Topics

• Adult
• Antigens, Human Platelet
• Blood Platelets (immunology)
• Blood Transfusion, Intrauterine
• Female
• Fetal Blood (cytology)
• Fetal Diseases (diagnosis, therapy)
• Humans
• Infant, Newborn
• Injections, Intravenous
• Integrin beta3
• Male
• Maternal-Fetal Exchange (immunology)
• Platelet Count
• Platelet Transfusion
• Pregnancy
• Thrombocytopenia (congenital, diagnosis, therapy)
• gamma-Globulins (administration & dosage)