Antitumor action of retinoids: inhibition of tumor cell line-induced angiogenesis and prevention of tumors in mice.

Abstract

Acitretin was shown to inhibit angiogenic response to the tumorigenic SKV cell line bearing HPV16 genome and to sarcoma L-1 cell line, both in vitro and in vivo systems. The lowered angiogenic response to tumor cells was independent of duration and timing of the application of acitretin to animals. Acitretin, but not etretinate, was also found to be effective in the prevention of sarcoma tumors in mice.

• Authors: A Szmurlo, M Marczak, S Jablonska, W Bollag
• Journal: Dermatology (Basel, Switzerland) (Dermatology) Vol. 184 Issue 2 Pg. 116-9 ( 1992) ISSN: 1018-8665 [Print] Switzerland
• PMID: 1379857 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Tretinoin
• Etretinate
• Acitretin

Topics

• Acitretin
• Animals
• Etretinate (pharmacology, therapeutic use)
• HeLa Cells
• Humans
• Mice
• Mice, Inbred BALB C
• Neovascularization, Pathologic
• Sarcoma, Experimental (prevention & control)
• Tretinoin (analogs & derivatives, pharmacology, therapeutic use)
• Tumor Cells, Cultured