Abstract |
The comparative effects of inorganic and organic tin compounds on chromosomes were assessed in human peripheral blood lymphocytes of healthy donors 20-40 years of age. The endpoints observed were chromosomal abnormalities, sister-chromatid exchanges (SCEs) and cell cycle kinetics. The maximum concentrations which reduced the replicative index by about 50%, of stannic chloride and trimethyltin chloride were 40 micrograms and 2 micrograms per culture respectively. The tested doses were 20 micrograms and 10 micrograms of stannic chloride and 1 microgram and 0.5 microgram of trimethyltin chloride. Both doses of stannic chloride induced a much higher frequency of chromosomal abnormalities (P less than 0.05-P less than 0.001) and a greater reduction of cell cycle kinetics than the corresponding relative doses of trimethyltin chloride. The frequencies of SCEs/cell induced by the latter were, however, slightly higher than those induced by the former.
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Authors | B B Ganguly, G Talukdar, A Sharma |
Journal | Mutation research
(Mutat Res)
Vol. 282
Issue 2
Pg. 61-7
(Jun 1992)
ISSN: 0027-5107 [Print] Netherlands |
PMID | 1377352
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organometallic Compounds
- Tin
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Topics |
- Cell Cycle
(drug effects)
- Chromosome Aberrations
- Humans
- In Vitro Techniques
- Lymphocytes
(drug effects)
- Mutagenesis
- Organometallic Compounds
(toxicity)
- Sister Chromatid Exchange
(drug effects)
- Tin
(toxicity)
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