Abstract |
Histamine-releasing autoantibodies have been identified in chronic idiopathic urticaria. 8 patients with severe disease and histamine-releasing activity in their sera underwent plasmapheresis. Symptoms were abolished for 2 months in 1 patient and for 3 weeks in another, 2 showed almost complete resolution of symptoms, 2 had temporary relief, and the other 2 showed little change. Further investigation in 4 of the patients showed significantly reduced skin-test responses to fresh post-exchange autologous sera after plasmapheresis compared with stored pre-exchange sera, but the response to intradermal histamine remained unchanged. Blood cellular histamine increased as in-vitro serum histamine-releasing activity fell after plasmapheresis. These results favour a pathogenetic role for histamine-releasing autoantibodies in patients with chronic urticaria.
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Authors | C E Grattan, D M Francis, N G Slater, R J Barlow, M W Greaves |
Journal | Lancet (London, England)
(Lancet)
Vol. 339
Issue 8801
Pg. 1078-80
(May 02 1992)
ISSN: 0140-6736 [Print] England |
PMID | 1373787
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Autoantibodies
(metabolism)
- Female
- Histamine
(blood)
- Histamine Release
- Humans
- Male
- Middle Aged
- Plasmapheresis
- Urticaria
(metabolism, therapy)
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