[Late pulmonary changes following bleomycin administration in computed tomography. Nodular fibrosis mimicking a seminoma metastasis].

Abstract

This is a case report of a patient with multiple metastases to the lung due to a seminoma, treated with a chemotherapeutic regimen containing bleomycin. The typical subpleural fibrosis of the lung related to bleomycin damage disappeared 6 months after the start of chemotherapy. 4 weeks later, a solitary nodule at a prior unchanged site of the lung appeared, mimicking recurrent metastasis. Explorative thoracotomy revealed a nodular fibrosis of the lung, representing a late reaction of the lung to chemotherapy damage.

• Authors: H B Gehl, S Hauptmann, M Sohn, K Bohndorf
• Journal: Der Radiologe (Radiologe) Vol. 32 Issue 2 Pg. 80-2 (Feb 1992) ISSN: 0033-832X [Print] Germany
• Vernacular Title: Pulmonale Spätveränderung nach Bleomycingabe in der Computertomographie. Rundherdförmige Fibrose unter dem Bild einer Seminommetastase.
• PMID: 1373509 (Publication Type: Case Reports, Journal Article)

Chemical References

• Bleomycin

Topics

• Adult
• Bleomycin (adverse effects)
• Diagnosis, Differential
• Dysgerminoma (drug therapy, secondary)
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Male
• Pulmonary Fibrosis (chemically induced, diagnostic imaging)
• Testicular Neoplasms (drug therapy, pathology)
• Time Factors
• Tomography, X-Ray Computed