Alkyllysophospholipid prevents induction of experimental allergic encephalomyelitis.

Alkyllysophospholipids are synthetic analogues of natural phospholipids possessing a high immunomodulating and antitumoral capacity. Experimental autoimmune encephalomyelitis is a model disease for multiple sclerosis which can be induced by injecting rats with myelin basic protein, MBP. The effect of one alkyllysophospholipid, ET-18-OCH3, on the course of experimental autoimmune encephalomyelitis was investigated. It was found that animals treated with ET-18-OCH3 showed only weak signs of disease. MBP specific T-cell lines were co-cultivated with ET-18-OCH3. The compound suppressed T-cell proliferation markedly, suggesting that this might be its mode of action in vivo. Since ET-18-OCH3 has only low toxicity in man, it could be of interest to perform further studies on its effects on autoimmune, demyelinating disease.
AuthorsA Klein-Franke, P G Munder
JournalJournal of autoimmunity (J Autoimmun) Vol. 5 Issue 1 Pg. 83-91 (Feb 1992) ISSN: 0896-8411 [Print] ENGLAND
PMID1373062 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Adjuvants, Immunologic
  • Myelin Basic Protein
  • Phospholipid Ethers
  • edelfosine
  • Adjuvants, Immunologic (administration & dosage)
  • Animals
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental (immunology, pathology, prevention & control)
  • Female
  • Lymphocyte Activation
  • Myelin Basic Protein
  • Phospholipid Ethers (administration & dosage)
  • Rats
  • Rats, Inbred Lew
  • T-Lymphocytes

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