Antibiotics from basidiomycetes. XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty.

Abstract

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 microM) and Moloney murine leukemia virus (Ki 68 microM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

• Authors: G Erkel, T Anke, A Gimenez, W Steglich
• Journal: The Journal of antibiotics (J Antibiot (Tokyo)) Vol. 45 Issue 1 Pg. 29-37 (Jan 1992) ISSN: 0021-8820 [Print] England
• PMID: 1372310 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiviral Agents
• Reverse Transcriptase Inhibitors
• Sesquiterpenes
• clavicoronic acid

Topics

• Animals
• Antiviral Agents (pharmacology)
• Avian Myeloblastosis Virus (drug effects, enzymology)
• Basidiomycota (metabolism)
• Cell Line
• Fermentation
• Magnetic Resonance Spectroscopy
• Mass Spectrometry
• Molecular Conformation
• Molecular Structure
• Moloney murine leukemia virus (drug effects, enzymology)
• Retroviridae (drug effects, enzymology)
• Reverse Transcriptase Inhibitors
• Sesquiterpenes (chemistry, pharmacology)
• Vesicular stomatitis Indiana virus (drug effects, enzymology)