Chalcone tetramers, lophirachalcone and alatachalcone, from Lophira alata as possible anti-tumor promoters.

Abstract	Two chalcone tetramers were isolated as inhibitors of Epstein-Barr virus (EBV)-activation induced by a tumor promoter, teleocidin B-4, from a medicinal plant in tropical west Africa, Lophira alata (Ochnaceae). One of them was identified as lophirachalcone. The other, named alatachalcone, was new, and the structure was determined by spectral properties. Both compounds also showed potent inhibitory activities against teleocidin B-4-induced inflammation on mouse ear. In an initiation-promotion experiment on mouse skin, alatachalcone (16 nmol) significantly inhibited tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate (TPA, 1.6 nmol).
Authors	A Murakami, S Tanaka, H Ohigashi, M Hirota, R Irie, N Takeda, A Tatematsu, K Koshimizu
Journal	Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 56 Issue 5 Pg. 769-72 (May 1992) ISSN: 0916-8451 [Print] England
PMID	1369383 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Anticarcinogenic Agents Antiviral Agents Chalcones Irritants Lyngbya Toxins Macromolecular Substances Phenols Plant Extracts lophirachalcone alatachalcone teleocidins 9,10-Dimethyl-1,2-benzanthracene Chalcone
Topics	9,10-Dimethyl-1,2-benzanthracene Animals Anticarcinogenic Agents (isolation & purification, therapeutic use) Antiviral Agents (isolation & purification, pharmacology) Chalcone (analogs & derivatives, chemistry, isolation & purification, pharmacology, therapeutic use) Chalcones Female Herpesvirus 4, Human (drug effects) Inflammation (chemically induced, drug therapy) Irritants Lyngbya Toxins Macromolecular Substances Mice Mice, Inbred ICR Phenols (chemistry, isolation & purification, pharmacology) Plant Extracts (isolation & purification, therapeutic use) Plants, Medicinal (chemistry) Skin Neoplasms (chemically induced, prevention & control)

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