Effects of L-156,602, a C5a receptor antagonist, on mouse experimental models of inflammation.

Abstract

L-156,602, a C5a receptor antagonist, was found as an immunosuppressant with preferential effects on delayed-type hypersensitivity (DTH) in our screening program and it was shown that L-156,602 suppressed the efferent phase of DTH. Here, we tested its effects on experimental models of inflammation induced in mice. L-156,602 did not suppress serotonin- and carrageenan- induced inflammation while it completely suppressed concanavalin A-induced inflammation 4 h after elicitation. The inflammation appeared 24 h after the elicitation with concanavalin A and it was significantly suppressed by L-156,602. Muramyl dipeptide (MDP)-induced acute joint inflammation was also significantly suppressed by L-156,602. These results demonstrated the unique immunomodulating properties of L-156,602 in mouse experimental models of inflammation.

• Authors: R F Tsuji, J Magae, K Nagai, M Yamasaki
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 56 Issue 12 Pg. 2034-6 (Dec 1992) ISSN: 0916-8451 [Print] England
• PMID: 1369097 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Peptides, Cyclic
• Receptor, Anaphylatoxin C5a
• Receptors, Complement
• PD 124966
• Concanavalin A
• Serotonin
• Complement C5a
• Carrageenan

Topics

• Animals
• Carrageenan
• Complement C5a (antagonists & inhibitors)
• Concanavalin A
• Female
• Inflammation (chemically induced, physiopathology)
• Mice
• Mice, Inbred BALB C
• Mice, Inbred Strains
• Mice, Nude
• Mice, SCID
• Peptides, Cyclic (pharmacology)
• Receptor, Anaphylatoxin C5a
• Receptors, Complement (antagonists & inhibitors)
• Serotonin