Abstract | BACKGROUND: METHODS: Forty-eight hypertensive renal transplant recipients on a stable dose of CsA were randomized in a double-blind, parallel-group manner to receive either amlodipine (n = 24) or tertatolol (n = 24) for 60 days. The primary outcome measure was the change from baseline in serum uric acid concentration. Secondary analyses of efficacy were based on changes in renal function and blood pressure. RESULTS:
Amlodipine significantly decreased serum uric acid levels from 483 +/- 99 to 431 +/- 110 microM/l (P < 0.001), while tertatolol significantly increased uric acid from 450 +/- 98 to 476 +/-84 microM/l (P = 0.006). Amlodipine also significantly increased glomerular filtration rate (P = 0.0048) and the clearance rate of uric acid (P = 0.023) and it reduced the fractional proximal tubular reabsorption of sodium (P < 0.001), compared with tertatolol. Renal plasma flow and filtered fraction were unaffected by both treatments, as was trough CsA blood concentration. Amlodipine lowered systolic blood pressure to a significantly greater extent than did tertatolol (P = 0.007). The time-dependent profile of diastolic blood pressure did not differ significantly between treatment groups. Both drugs were well tolerated. CONCLUSIONS:
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Authors | Jacques Chanard, Olivier Toupance, Sylvie Lavaud, Bruno Hurault de Ligny, Corine Bernaud, Bruno Moulin |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 18
Issue 10
Pg. 2147-53
(Oct 2003)
ISSN: 0931-0509 [Print] England |
PMID | 13679494
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunosuppressive Agents
- Propanolamines
- Thiophenes
- Vasodilator Agents
- Amlodipine
- Cyclosporine
- tertatolol
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Topics |
- Adult
- Amlodipine
(administration & dosage)
- Cyclosporine
(administration & dosage, adverse effects)
- Double-Blind Method
- Female
- Follow-Up Studies
- Graft Rejection
- Graft Survival
- Humans
- Hypertension
(chemically induced, drug therapy)
- Hyperuricemia
(chemically induced, drug therapy)
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Kidney Function Tests
- Kidney Transplantation
- Male
- Middle Aged
- Propanolamines
(administration & dosage)
- Reference Values
- Risk Assessment
- Thiophenes
(administration & dosage)
- Transplantation Immunology
- Treatment Outcome
- Vasodilator Agents
(administration & dosage)
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