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Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice.

Abstract
We investigated the effect of Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang), a Japanese herbal medicine, and found that 1000 mg/kg p.o. improved the scopolamine-induced impairment of passive avoidance response in mice. Further, the same dose of Ninjin-yoei-to enhanced oxotremorine-induced tremors in mice. The water extract of Polygalae radix, one of the constituent herbs of Ninjin-yoei-to, at a dose of 100 mg/kg significantly improved the scopolamine-induced impairment of passive avoidance response and enhanced oxotremorine-induced tremors in mice. Moreover, the enhancement of oxotremorine-induced tremors by Ninjin-yoei-to (1000 mg/kg) and Polygalae radix (100 mg/kg) was completely antagonized by pretreatment of scopolamine hydrobromide (0.5 mg/kg). These results suggest that Ninjin-yoei-to may improve the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system and that Polygalae radix may be involved in the action of Ninjin-yoei-to.
AuthorsN Egashira, M Yuzurihara, N Hattori, I Sakakibara, A Ishige
JournalPhytomedicine : international journal of phytotherapy and phytopharmacology (Phytomedicine) Vol. 10 Issue 6-7 Pg. 467-73 ( 2003) ISSN: 0944-7113 [Print] Germany
PMID13678229 (Publication Type: Journal Article)
Chemical References
  • Drugs, Chinese Herbal
  • Immunologic Factors
  • Muscarinic Agonists
  • Plant Extracts
  • Oxotremorine
  • Scopolamine
Topics
  • Administration, Oral
  • Animals
  • Behavior, Animal (drug effects)
  • Dose-Response Relationship, Drug
  • Drugs, Chinese Herbal (administration & dosage, pharmacology, therapeutic use)
  • Immunologic Factors (administration & dosage, pharmacology, therapeutic use)
  • Japan
  • Male
  • Medicine, Traditional
  • Mice
  • Muscarinic Agonists (administration & dosage, pharmacology, therapeutic use)
  • Oxotremorine
  • Panax
  • Phytotherapy
  • Plant Extracts (administration & dosage, pharmacology, therapeutic use)
  • Polygala
  • Scopolamine
  • Tremor (chemically induced, drug therapy)

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