[Studies on the teratogenic potential of p-tert-butylphenolformaldehyde resin in rats].

Abstract

p-tert-Butylphenolformaldehyde resin, an adhesive, was given orally to pregnant Wistar rats by stomach intubation at the dose levels of 250, 500 and 1000 mg/kg body weight during days 7 to 17 of gestation, and the effects of the compound on dams and fetal developments were examined. No changes in general conditions, maternal body weight, food consumption, numbers of corpora lutea and implantation ratio were observed. There was no evidence of an increase in fetal death or of malformation attributable to the treatment with p-tert-butylphenolformaldehyde resin in any of dose levels examined. It was concluded that p-tert-butylphenolformaldehyde resin has no teratogenic effect in rats.

• Authors: R Tanaka, M Usami, K Kawashima, A Takanaka
• Journal: Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences (Eisei Shikenjo Hokoku) Issue 110 Pg. 22-6 ( 1992) ISSN: 0077-4715 [Print] Japan
• PMID: 1364431 (Publication Type: English Abstract, Journal Article)

Chemical References

• Resins, Synthetic
• p-tert-butylphenolformaldehyde resin

Topics

• Administration, Oral
• Animals
• Embryonic and Fetal Development (drug effects)
• Female
• Male
• Pregnancy
• Pregnancy, Animal (drug effects)
• Rats
• Rats, Wistar
• Resins, Synthetic (administration & dosage, toxicity)