[Tropaphen in experimental drug therapy of cor pulmonale].

Abstract

The influence of alpha-adrenoblocking drug tropaphen on cardio- and haemodynamics under experimental lung-heart failure was studied in dogs. The findings suggest effectiveness of tropaphen administration in such pathology shown by a decrease of lung hypertension and heart overload, significant increase of the contractile activity and relaxation properties of myocardium of both ventricles and in cardiac pump function optimization.

• Authors: S B Frantsuzova, L L Arshinnikova, L I Antonenko, V P Iatsenko
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 114 Issue 9 Pg. 244-6 (Sep 1992) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Tropafen v éksperimenta'noĭ farmakoterapii legochnogo serdtsa.
• PMID: 1362091 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Adrenergic alpha-Antagonists
• Parasympatholytics
• Tropanes
• tropodifene

Topics

• Adrenergic alpha-Antagonists (therapeutic use)
• Animals
• Dogs
• Female
• Heart (physiopathology)
• Hypertension, Pulmonary (drug therapy)
• Male
• Myocardial Contraction
• Parasympatholytics (therapeutic use)
• Pulmonary Heart Disease (drug therapy, physiopathology)
• Tropanes (therapeutic use)