Abstract |
The effects of dermorphin on EEG and autonomic variables are compared with the effects of 2 analogues and 2 homologues, all administered intracerebroventricularly in the rabbit. Dermorphin was the most effective in modifying all considered parameters: increase of cortically derived and calculated total power, bradycardia, respiratory depression and hypothermia. The dibenzylated heptapeptide was essentially inactive. The electrocortical pattern induced by the administration of L- dermorphin suggests a functional correlation between the amino acid D-ala 2 and the effects on EEG. Comparison between the effects produced by the N-terminal tetrapeptide and pentapeptide led us to hypothesize that amino acid Tyr 5 may be specifically involved in inducing the autonomic effects.
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Authors | E Marchioni, M Maurelli, A Tartara |
Journal | Neuropsychobiology
(Neuropsychobiology)
Vol. 26
Issue 1-2
Pg. 81-8
( 1992)
ISSN: 0302-282X [Print] Switzerland |
PMID | 1361972
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Opioid
- Oligopeptides
- Opioid Peptides
- Peptides
- dermorphin
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Topics |
- Analgesics, Opioid
(pharmacology)
- Animals
- Autonomic Nervous System
(drug effects)
- Body Temperature Regulation
(drug effects)
- Cerebral Cortex
(drug effects)
- Electroencephalography
(drug effects, instrumentation)
- Evoked Potentials
(drug effects)
- Heart Rate
(drug effects)
- Oligopeptides
(pharmacology)
- Opioid Peptides
- Peptides
(pharmacology)
- Rabbits
- Respiration
(drug effects)
- Signal Processing, Computer-Assisted
(instrumentation)
- Structure-Activity Relationship
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