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Quantitative EEG and autonomic patterns of synthetic peptides related to dermorphin.

Abstract
The effects of dermorphin on EEG and autonomic variables are compared with the effects of 2 analogues and 2 homologues, all administered intracerebroventricularly in the rabbit. Dermorphin was the most effective in modifying all considered parameters: increase of cortically derived and calculated total power, bradycardia, respiratory depression and hypothermia. The dibenzylated heptapeptide was essentially inactive. The electrocortical pattern induced by the administration of L-dermorphin suggests a functional correlation between the amino acid D-ala 2 and the effects on EEG. Comparison between the effects produced by the N-terminal tetrapeptide and pentapeptide led us to hypothesize that amino acid Tyr 5 may be specifically involved in inducing the autonomic effects.
AuthorsE Marchioni, M Maurelli, A Tartara
JournalNeuropsychobiology (Neuropsychobiology) Vol. 26 Issue 1-2 Pg. 81-8 ( 1992) ISSN: 0302-282X [Print] Switzerland
PMID1361972 (Publication Type: Journal Article)
Chemical References
  • Analgesics, Opioid
  • Oligopeptides
  • Opioid Peptides
  • Peptides
  • dermorphin
Topics
  • Analgesics, Opioid (pharmacology)
  • Animals
  • Autonomic Nervous System (drug effects)
  • Body Temperature Regulation (drug effects)
  • Cerebral Cortex (drug effects)
  • Electroencephalography (drug effects, instrumentation)
  • Evoked Potentials (drug effects)
  • Heart Rate (drug effects)
  • Oligopeptides (pharmacology)
  • Opioid Peptides
  • Peptides (pharmacology)
  • Rabbits
  • Respiration (drug effects)
  • Signal Processing, Computer-Assisted (instrumentation)
  • Structure-Activity Relationship

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