The erbB-3 gene in human pancreatic cancer.

Abstract

Abnormalities of the type 1 growth factor receptor family have been implicated in the pathogenesis of pancreatic cancer. There is evidence for a potential autocrine loop involving overexpression of the epidermal growth factor (EGF) receptor and its ligands, as well as overexpression of the erbB-2 receptor. A third member of this receptor family, erbB-3, has recently been recognized and found to be abnormally expressed in some types of human cancer. In this study we show that overexpression of the erbB-3 protein occurs very frequently in carcinoma of the exocrine pancreas and also in chronic pancreatitis. We found no evidence of amplification or rearrangement of the erbB-3 gene by Southern blot analysis of DNA from pancreatic cancer cells lines.

• Authors: N R Lemoine, M Lobresco, H Leung, C Barton, C M Hughes, S A Prigent, W J Gullick, G Klöppel
• Journal: The Journal of pathology (J Pathol) Vol. 168 Issue 3 Pg. 269-73 (Nov 1992) ISSN: 0022-3417 [Print] England
• PMID: 1361525 (Publication Type: Journal Article)

Chemical References

• Oncogene Proteins v-erbB
• Proto-Oncogene Proteins
• Retroviridae Proteins, Oncogenic
• ErbB Receptors
• Receptor, ErbB-3

Topics

• Amino Acid Sequence
• Blotting, Southern
• Cell Line
• Chronic Disease
• ErbB Receptors (genetics)
• Gene Amplification
• Gene Expression (genetics)
• Gene Rearrangement
• Humans
• Immunohistochemistry
• Molecular Sequence Data
• Oncogene Proteins v-erbB
• Pancreas (chemistry)
• Pancreatic Neoplasms (genetics, metabolism)
• Pancreatitis (genetics, metabolism)
• Proto-Oncogene Proteins (analysis, genetics)
• Receptor, ErbB-3
• Retroviridae Proteins, Oncogenic (genetics)