Difenacoum poisoning as a cause of haematuria.

Abstract

A man presented with frank haematuria and a grossly prolonged prothrombin time. He was later found to have taken an overdose of difenacoum--a 'superwarfarin' rodenticide. The diagnosis was confirmed by a serum concentration of difenacoum of 0.6 micrograms ml-1. Overdosage with superwarfarins is discussed and the need for prolonged treatment with vitamin K1 highlighted.

• Authors: G P Butcher, M J Shearer, A D MacNicoll, M J Kelly, P W Ind
• Journal: Human & experimental toxicology (Hum Exp Toxicol) Vol. 11 Issue 6 Pg. 553-4 (Nov 1992) ISSN: 0960-3271 [Print] England
• PMID: 1361149 (Publication Type: Case Reports, Journal Article)

Chemical References

• 4-Hydroxycoumarins
• Rodenticides
• Vitamin K
• difenacoum

Topics

• 4-Hydroxycoumarins (blood, poisoning)
• Adult
• Drug Overdose
• Hematuria (chemically induced, drug therapy, physiopathology)
• Humans
• Male
• Prothrombin Time
• Rodenticides (blood, poisoning)
• Vitamin K (therapeutic use)