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Disposition of mesalazine from mesalazine-delivering drugs in patients with inflammatory bowel disease, with and without diarrhoea.

Abstract
The disposition of mesalazine from the azo compounds sulphasalazine and olsalazine (Dipentum) and from the slow-release mesalazine drugs Pentasa, Asacol, and Salofalk was studied in 20 patients with inflammatory bowel disease. Ten of them had diarrhoea, and 10 had normal stools. On the last 2 days of a 7-day maintenance treatment with each of the study drugs urine and faeces were collected for determination of mesalazine, acetyl-mesalazine, and unsplit azo compound. In patients with and without diarrhoea the urinary and the faecal excretion of acetyl-mesalazine was lowest during treatment with olsalazine. The proportion of acetyl-mesalazine in faeces was highest during treatment with Pentasa in both groups. The presence of diarrhoea was associated with a decrease in the proportion of acetyl-mesalazine in faeces during treatment with all drugs, not significant only for Pentasa. The proportion of unsplit azo compound in faeces increased in the case of diarrhoea to almost 50%. It is concluded that in patients with inflammatory bowel disease diarrhoea substantially influences the disposition from all these drugs except Pentasa.
AuthorsM C Rijk, A van Schaik, J H van Tongeren
JournalScandinavian journal of gastroenterology (Scand J Gastroenterol) Vol. 27 Issue 10 Pg. 863-8 (Oct 1992) ISSN: 0036-5521 [Print] NORWAY
PMID1359629 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Aminosalicylic Acids
  • Delayed-Action Preparations
  • Drug Carriers
  • Sulfasalazine
  • Mesalamine
  • olsalazine
Topics
  • Adult
  • Aged
  • Aminosalicylic Acids (chemistry, pharmacokinetics, therapeutic use, urine)
  • Delayed-Action Preparations (standards)
  • Diarrhea (etiology)
  • Drug Carriers
  • Feces (chemistry)
  • Female
  • Gastrointestinal Transit
  • Humans
  • Inflammatory Bowel Diseases (complications, drug therapy, urine)
  • Male
  • Mesalamine
  • Middle Aged
  • Sulfasalazine (therapeutic use)

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