Abstract |
The dietary administration of the calcium channel blocker oxodipine to Fischer (F344) rats for 12 and 30 months resulted in increased incidence of altered hepatocytic foci (AHF). As the Environmental Protection Agency (EPA) regards AHF as potentially precancerous it is important to accumulate experimental evidence which may negate this theory. In the case of oxodipine we proved that with dosages close to maximum tolerated dose (MTD) for prolonged periods no hepatic neoplasms were produced. The possible nature of such AHF is discussed.
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Authors | A Nyska, T Waner, A Galiano, B Klein |
Journal | Pharmacology & toxicology
(Pharmacol Toxicol)
Vol. 70
Issue 6 Pt 1
Pg. 439-42
(Jun 1992)
ISSN: 0901-9928 [Print] Denmark |
PMID | 1359524
(Publication Type: Journal Article)
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Chemical References |
- Calcium Channel Blockers
- Dihydropyridines
- gamma-Glutamyltransferase
- Alkaline Phosphatase
- oxodipine
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Topics |
- Alkaline Phosphatase
(blood, drug effects)
- Animals
- Calcium Channel Blockers
(toxicity)
- Dihydropyridines
(toxicity)
- Female
- Hypertrophy
(chemically induced)
- Liver
(anatomy & histology, drug effects, pathology)
- Male
- Organ Size
(drug effects)
- Rats
- Rats, Inbred F344
- Time Factors
- gamma-Glutamyltransferase
(blood, drug effects)
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