Anti-inflammatory activity of oleanolic acid in rats and mice.

Abstract

Oleanolic acid displayed anti-inflammatory activity in carrageenan and dextran-induced oedema in rats. It elicited marked anti-arthritic action in adjuvant-induced polyarthritis in rats and mice and in formaldehyde-induced arthritis in rats. Oleanolic acid checked the inflammation-induced increased serum transaminase levels. It reduced exudate volume and inhibited leucocyte infiltration in carrageenan-induced pleurisy in rats. It is devoid of any analgesic, antipyretic or ulcerogenic action. Oleanolic acid did not affect the parturition time in pregnant rats or castor oil-induced diarrhoea in rats. Oral LD50 was found to be greater than 2 g kg-1 in mice and rats.

• Authors: G B Singh, S Singh, S Bani, B D Gupta, S K Banerjee
• Journal: The Journal of pharmacy and pharmacology (J Pharm Pharmacol) Vol. 44 Issue 5 Pg. 456-8 (May 1992) ISSN: 0022-3573 [Print] England
• PMID: 1359067 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Formaldehyde
• Oleanolic Acid
• Carrageenan
• Transaminases

Topics

• Adrenalectomy
• Animals
• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, toxicity)
• Arthritis, Experimental (drug therapy)
• Behavior, Animal (drug effects)
• Carrageenan
• Diarrhea (chemically induced, prevention & control)
• Edema (chemically induced, prevention & control)
• Female
• Formaldehyde
• Gossypium
• Labor, Obstetric (drug effects)
• Male
• Mice
• Oleanolic Acid (pharmacology, toxicity)
• Pleurisy (chemically induced, prevention & control)
• Pregnancy
• Rats
• Seeds (chemistry)
• Stomach Ulcer (chemically induced)
• Transaminases (blood)