Pharmacological properties of pempidine (1:2:2:6:6-pentamethylpiperidine), a new ganglion-blocking compound.

Abstract

Pempidine (1:2:2:6:6-pentamethylpiperidine) is a long-acting ganglion-blocking compound which is effective by mouth. By intravenous injection it has a similar potency to hexamethonium on the preganglionically stimulated nictitating membrane of the cat. The compound blocks the effects of intravenous nicotine and of peripheral vagal stimulation on the blood pressure; it also causes dilatation of the pupil after removal of the sympathetic innervation. On the guinea-pig ileum, the predominant effect of the compound is to inhibit nicotine contractions. Pempidine is well absorbed from the gastro-intestinal tract as judged by (a) the low ratio (6.9) of oral to intravenous toxicities, (b) the rapid development of mydriasis in mice after oral administration of small doses, and (c) the rapid onset of hypotension when the compound is injected directly into the duodenum of anaesthetized cats. Other actions include neuromuscular paralysis of curare-like type when large doses of the compound are injected intravenously and central effects such as tremors which occur with near toxic doses. In cats with a low blood pressure, large intravenous doses have a slight pressor action.

• Authors: S J CORNE, N D EDGE
• Journal: British journal of pharmacology and chemotherapy (Br J Pharmacol Chemother) Vol. 13 Issue 3 Pg. 339-49 (Sep 1958) ISSN: 0366-0826 [Print] England
• PMID: 13584741 (Publication Type: Journal Article)

Chemical References

• Autonomic Agents
• Piperidines
• Nicotine
• Pempidine

Topics

• Animals
• Autonomic Agents
• Cats
• Ganglia
• Guinea Pigs
• Mice
• Nicotine
• Nictitating Membrane
• Pempidine
• Piperidines (pharmacology)