A method of assaying the anti-tetanus potency of drugs on experimental local tetanus in the rabbit.

Abstract

Local tetanus was induced in rabbits by the intramuscular injection of tetanus toxin. The relative potency of drugs which abolished the muscle spasm was determined using quantitative electromyography and the accuracy of the method tested with mephenesin and thiopentone. It is suggested that the method is suitable for screening new drugs for clinical use.

• Authors: D R LAURENCE, R A WEBSTER
• Journal: British journal of pharmacology and chemotherapy (Br J Pharmacol Chemother) Vol. 13 Issue 3 Pg. 330-3 (Sep 1958) ISSN: 0366-0826 [Print] England
• PMID: 13584739 (Publication Type: Journal Article)

Chemical References

• Tetanus Toxin
• Tetanus Toxoid
• Mephenesin
• Thiopental

Topics

• Animals
• Biological Assay
• Electromyography
• Injections, Intramuscular
• Mephenesin (pharmacology)
• Rabbits
• Tetanus
• Tetanus Toxin
• Tetanus Toxoid
• Thiopental (pharmacology)