Pharmacological properties of betabeta-di-methyl-acryloylcholine and some other beta-substituted acryloylcholines.

Abstract

The mammalian pharmacology of a new naturally occurring ester of choline, betabeta-dimethylacryloylcholine (DMAC), has been studied, mainly in the cat, together with that of two synthetic beta-substituted acryloylcholines, crotonoylcholine and pent-2-enoylcholine. Comparisons have been made with the reduced form of DMAC, isovalerylcholine, with another naturally ocurring beta-substituted acryloylcholine, murexine (urocanoylcholine), and with suxamethonium. DMAC has been shown to be a ganglion stimulating and neuromuscular blocking agent generally similar, in potency and properties, to murexine. It is also a powerful respiratory stimulant. The other unsaturated esters behaved similarly but were less potent.

• Authors: B HOLMSTEDT, V P WHITTAKER
• Journal: British journal of pharmacology and chemotherapy (Br J Pharmacol Chemother) Vol. 13 Issue 3 Pg. 308-14 (Sep 1958) ISSN: 0366-0826 [Print] England
• PMID: 13584734 (Publication Type: Journal Article)

Chemical References

• acryloylcholine
• murexine
• Succinylcholine
• Choline

Topics

• Animals
• Cats
• Choline (analogs & derivatives)
• Succinylcholine