Expression of only one of two types of mRNA transcribed from the serine dehydratase gene is repressed in hepatoma cells.

Abstract

The expressions of mRNA for serine dehydratase in H4IIE, HTC, and HepG2 hepatoma cells were investigated. Of the two types of mRNA transcribed from the single copy of the rat serine dehydratase gene, expression of only that encoding 35 kDa serine dehydratase is repressed in these cells. The other type coding the 8.9 kDa truncated translation product is expressed at a similar level to that in hepatocytes in primary culture and is not under hormonal control.

• Authors: K Matsuda, C Noda, A Ichihara
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 188 Issue 1 Pg. 336-43 (Oct 15 1992) ISSN: 0006-291X [Print] United States
• PMID: 1358067 (Publication Type: Journal Article)

Chemical References

• Oligodeoxyribonucleotides
• RNA, Messenger
• Tyrosine Transaminase
• L-Serine Dehydratase

Topics

• Alternative Splicing
• Animals
• Base Sequence
• Blotting, Northern
• Carcinoma, Hepatocellular (enzymology)
• Cells, Cultured
• Gene Expression Regulation, Enzymologic
• Gene Expression Regulation, Neoplastic
• Humans
• L-Serine Dehydratase (genetics, metabolism)
• Liver (enzymology)
• Liver Neoplasms (enzymology)
• Liver Neoplasms, Experimental (enzymology)
• Male
• Molecular Sequence Data
• Oligodeoxyribonucleotides
• RNA, Messenger (biosynthesis, genetics)
• Rats
• Rats, Wistar
• Transcription, Genetic
• Tumor Cells, Cultured
• Tyrosine Transaminase (metabolism)