HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression of SSEA-1 carbohydrate antigen correlates with stage, grade and metastatic potential of transitional cell carcinoma of the bladder.

Abstract
Expression of stage-specific embryonic antigen-1 (SSEA-1) was immunohistochemically analyzed in primary cancerous regions from transitional cell carcinoma of the bladder. Lymph node metastasis occurred in 14 (50%) of 28 patients with high expression of SSEA-1 antigen, but in only one (4%) of 23 patients with low or no expression. Of 36 invasive bladder carcinoma patients with no metastasis at operation, 8 (57%) of 14 with high expression of SSEA-1 antigen died of cancer or had metastasis, whereas 4 (18%) of 22 with low or no expression had progression of the disease. In addition, stage pT3b-4 tumors more frequently reacted with SSEA-1 MAb than stage pT1 tumors (p less than 0.01). Grade 2 or 3 tumors were also more reactive than grade 1 tumors, which were all unreactive except for one (p less than 0.01, respectively). Our data suggest that SSEA-1, which is a Le(x) antigen, correlates with stage and grade as well as metastatic phenotype of transitional cell carcinoma of the bladder.
AuthorsT Shirahama, M Ikoma, T Muramatsu, Y Ohi
JournalThe Journal of urology (J Urol) Vol. 148 Issue 4 Pg. 1319-22 (Oct 1992) ISSN: 0022-5347 [Print] United States
PMID1357195 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Lewis X Antigen
Topics
  • Carcinoma, Transitional Cell (chemistry, metabolism, pathology)
  • Humans
  • Lewis X Antigen (analysis, biosynthesis)
  • Lymphatic Metastasis
  • Neoplasm Staging
  • Urinary Bladder Neoplasms (chemistry, metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: