[Effects of amiridin and tacrine, drugs effective in Alzheimer's disease, on synaptosomal uptake of neuromediators].

Abstract

The study of the drugs effective in the treatment of cognitive deficits and memory loss associated with senile dementia of the Alzheimer's type--tacrine and amiridin, acetylcholinesterase inhibitor physostigmine and nootrop piracetam on uptake of 3H-serotonin (3H-5-HT), 3H-adrenaline (3H-AD), 3H-noradrenaline (3H-HA), 2H-dopamine (3H-DA), 3H-gamma-aminobutyric acid (3H-GABA), 3H-glutamic acid (3H-GLU), 3H-aspartic acid (3H-ASP) and 3H-glycine (3H-GLI) showed that tacrine and amiridin (5 x 10(-5) M) statistically significantly (P less than 0.05) inhibited the uptake of 3H-DA and 3H-5-HT. Physostigmine at concentration 5 x 10(-4) M statistically significantly (P less than 0.05) inhibited uptake of 3H-5-HT only. Piracetam at concentration range 1-5 x 10(-3) M had no effect on uptake of all investigated neurotransmitters. The above finding suggest that the uptake of neurotransmitter in nerve terminals is not the main target of amiridin and tacrine.

• Authors: Iu V Burov, T D Baĭmanov, N I Maĭsov
• Journal: Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 113 Issue 4 Pg. 379-81 (Apr 1992) ISSN: 0365-9615 [Print] Russia (Federation)
• Vernacular Title: Vliianie amiridina i takrina--preparatov, éffektivnykh pri bolezni Al'tsgeĭmera, na sinaptosomal'nyĭ zakhvat neĭromediatorov.
• PMID: 1356507 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aminoquinolines
• Cholinesterase Inhibitors
• Neurotransmitter Agents
• Psychotropic Drugs
• Serotonin
• Tacrine
• gamma-Aminobutyric Acid
• Physostigmine
• amiridine
• Dopamine
• Norepinephrine
• Epinephrine
• Piracetam

Topics

• Alzheimer Disease (drug therapy)
• Aminoquinolines (pharmacology)
• Animals
• Cholinesterase Inhibitors
• Dopamine (metabolism)
• Epinephrine (metabolism)
• Neurotransmitter Agents (metabolism)
• Norepinephrine (metabolism)
• Physostigmine (pharmacology)
• Piracetam (pharmacology)
• Psychotropic Drugs (pharmacology)
• Rats
• Serotonin (metabolism)
• Synaptosomes (drug effects, metabolism)
• Tacrine (pharmacology)
• gamma-Aminobutyric Acid (metabolism)