The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission.

Abstract

The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.

• Authors: E Petersen, B Høgh, M Dziegiel, M Borre, A Björkman, N T Marbiah, E Dolopaye, A P Hanson, S Jepsen
• Journal: Acta tropica (Acta Trop) Vol. 51 Issue 2 Pg. 135-42 (Jun 1992) ISSN: 0001-706X [Print] Netherlands
• PMID: 1354931 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Protozoan
• Immunoglobulin G
• Immunoglobulin M
• Protozoan Proteins
• glutamate-rich protein, Plasmodium

Topics

• Adolescent
• Adult
• Amino Acid Sequence
• Animals
• Antibodies, Protozoan (immunology)
• Female
• Humans
• Immunoglobulin G (immunology)
• Immunoglobulin M (immunology)
• Malaria, Falciparum (immunology)
• Male
• Molecular Sequence Data
• Plasmodium falciparum (immunology)
• Protozoan Proteins (immunology)