Abstract |
At an identified cholinergic synapse of the Aplysia buccal ganglion, presynaptic injections of guanosine 5'-O-3-thiotriphosphate ( GTP-gamma-S) depressed the amplitude of evoked postsynaptic responses. This reduction of acetylcholine (ACh) release by GTP-gamma-S, prevented by pre-injection of guanosine 5'-O-2-thiodiphosphate ( GDP-beta-S) in the presynaptic neuron, was due to a reduction of the number of ACh quanta released. The mean amplitude of the evoked miniature postsynaptic current (MPSC) was unchanged. The presynaptic Ca2+ influx was lowered.
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Authors | G Baux, P Fossier, L Tauc |
Journal | Brain research
(Brain Res)
Vol. 575
Issue 1
Pg. 155-8
(Mar 13 1992)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 1354552
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neurotransmitter Agents
- Guanosine 5'-O-(3-Thiotriphosphate)
- GTP-Binding Proteins
- Acetylcholine
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Topics |
- Acetylcholine
(physiology)
- Animals
- Aplysia
(metabolism)
- Evoked Potentials
(drug effects)
- GTP-Binding Proteins
(physiology)
- Guanosine 5'-O-(3-Thiotriphosphate)
(pharmacology)
- Iontophoresis
- Neurotransmitter Agents
(metabolism)
- Synapses
(metabolism)
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