The dose-effect relation and duration of action of 10 mg, 20 mg, 40 mg, and 80 mg
ridazolol on ischemic ST-segment depression in exercise-ECG were determined in a randomized, double-blind, acute, cross-over study of 15 patients with confirmed
coronary artery disease and reproducible ST-segment depression. Maximal reduction of ST-segment depression in comparison to placebo during constant exercise was 0.16 vs. 0.25 mm (n.s.) after 10 mg, 0.09 vs. 0.25 mm (p less than 0.01) after 20 mg, 0.11 vs. 0.25 mm (p less than 0.01) after 40 mg, and 0.07 vs. 0.25 mm (p less than 0.01) after 80 mg
ridazolol. A remarkable reduction of ST-segment depression under placebo was seen in the third and fifth hours after application. Systolic blood pressure under exercise was reduced significantly after 80 mg
ridazolol (145 vs. 176 mm Hg; (p less than 0.05) over a period of 5 h. Heart-rate was reduced significantly after 80 mg
ridazolol (102 vs. 131/min; p less than 0.05) for 5 h. Rate-pressure product after 20 mg (174 vs. 234 mm Hg/min; p less than 0.01), 40 mg (169 vs. 234 mm Hg/min; p less than 0.01), and 80 mg (153 vs. 234 mm Hg/min; p less than 0.01)
ridazolol was reduced significantly over 3 to 5 h. 20, 40 and 80 mg
ridazolol show a good antianginal and
antihypertensive efficacy. Blood pressure and heart-rate under exercise were significantly reduced over 5 h. In contrast, improvement of ST-segment depression only lasted 1 h.
Ridazolol was well tolerated.