DNA damage induced by hypocrellin-A photosensitization.

Abstract

Hypocrellin-A (HC-A) isolated from Hypocrellia bambusae Sacc., is a new and effective photosensitizer. Illumination of sarcoma 180 cells with visible light in the presence of HC-A leads to a decrease in cell viability and 3H-TdR incorporation, causes DNA strand breakage, and results in the selective destruction of guanine moieties in DNA. HC-A photosensitization causes an increase in the theta 260/theta 280 ratio in the circular dichroism spectra of DNA in vitro. Of the four usual 2'-deoxynucleotides illuminated in the presence of HC-A only 2'-deoxyguanylic acid was destroyed.

• Authors: E H Cao, S M Xin, L S Cheng
• Journal: International journal of radiation biology (Int J Radiat Biol) Vol. 61 Issue 2 Pg. 213-9 (Feb 1992) ISSN: 0955-3002 [Print] England
• PMID: 1351909 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• DNA, Single-Stranded
• Drugs, Chinese Herbal
• Quinones
• Radiation-Sensitizing Agents
• Phenol
• Perylene
• hypocrellin A

Topics

• Animals
• Cell Division (drug effects)
• DNA Damage
• DNA, Single-Stranded (drug effects)
• Drugs, Chinese Herbal (pharmacology)
• Perylene (analogs & derivatives, pharmacology)
• Phenol
• Photolysis
• Quinones (pharmacology)
• Radiation-Sensitizing Agents (pharmacology)