HLA-DP antigen and Takayasu arteritis.

Abstract	Sixty-four patients with Takayasu arteritis and 317 healthy individuals in the Japanese population were examined for HLA-A, -B and -C alleles by serological typing and for HLA-DR, DQ and DP alleles by DNA typing using PCR/SSOP analysis. The frequencies of HLA-Bw52, DRB11502, DRB50102, DQA10103, DQB10601 and DPB10901 alleles were significantly increased and the frequencies of HLA-Bw54, DRB10405, DRB40101, DQA10301, DQB10401 alleles were significantly decreased. Strong linkage disequilibria among the increased alleles and among the decreased alleles were evident in the Japanese population. Therefore, the combination or haplotype of HLA-Bw52-DRB11502-DRB50102-DQA10103-DQB10601 -DPA102-DPB10901 may confer susceptibility to Takayasu arteritis while another combination or haplotype of HLA-Bw54-DRB10405-DRB40101-DQA10301-DQB1++ +0401 may confer resistance to the disease. Because this is the first evidence for the association between an HLA-DP allele and Takayasu arteritis, we examined the nucleotide sequences of the DPB10901 allele from a patient and her healthy relatives and found no difference. The disease is therefore not caused by a mutated DPB1 gene.
Authors	R P Dong, A Kimura, F Numano, M Yajima, Y Hashimoto, Y Kishi, Y Nishimura, T Sasazuki
Journal	Tissue antigens (Tissue Antigens) Vol. 39 Issue 3 Pg. 106-10 (Mar 1992) ISSN: 0001-2815 [Print] England
PMID	1350869 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	HLA-A Antigens HLA-B Antigens HLA-C Antigens HLA-DP Antigens HLA-DQ Antigens HLA-DR Antigens Histocompatibility Antigens Class I Histocompatibility Antigens Class II DNA
Topics	Alleles Base Sequence DNA (analysis, genetics) Female HLA-A Antigens (analysis, genetics) HLA-B Antigens (analysis, genetics) HLA-C Antigens (analysis, genetics) HLA-DP Antigens (analysis, genetics) HLA-DQ Antigens (analysis, genetics) HLA-DR Antigens (analysis, genetics) Histocompatibility Antigens Class I (analysis, genetics) Histocompatibility Antigens Class II (analysis, genetics) Humans Japan (epidemiology) Male Molecular Sequence Data Pedigree Polymerase Chain Reaction Takayasu Arteritis (epidemiology, genetics, immunology)

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