Does pralidoxime affect outcome of management in acute organophosphorus poisoning?

Abstract

Acute organophosphorus (OP) poisoning is usually treated with atropine plus cholinesterase reactivators such as oximes, but controlled trials to assess the efficacy of oximes in OP poisoning have not been done. A period when the acetyl cholinesterase reactivator pralidoxime chloride was not available in Sri Lanka gave us the opportunity to compare atropine alone for treatment of moderate to severe OP poisoning (21 patients) with atropine plus pralixodime (24 patients). Outcome, as assessed clinically, was similar in the two groups. These results cast doubt on the necessity of cholinesterase reactivators for treatment of acute OP poisoning.

• Authors: H J de Silva, R Wijewickrema, N Senanayake
• Journal: Lancet (London, England) (Lancet) Vol. 339 Issue 8802 Pg. 1136-8 (May 09 1992) ISSN: 0140-6736 [Print] England
• PMID: 1349368 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Cholinesterase Reactivators
• Pralidoxime Compounds
• Atropine
• pralidoxime

Topics

• Adolescent
• Adult
• Aged
• Atropine (administration & dosage, therapeutic use)
• Cholinesterase Reactivators (administration & dosage, pharmacology, therapeutic use)
• Critical Care (statistics & numerical data)
• Drug Therapy, Combination
• Female
• Humans
• Length of Stay (statistics & numerical data)
• Male
• Middle Aged
• Organophosphate Poisoning
• Poisoning (drug therapy, epidemiology, mortality)
• Pralidoxime Compounds (administration & dosage, pharmacology, therapeutic use)
• Sri Lanka (epidemiology)
• Treatment Outcome
• Ventilators, Mechanical (statistics & numerical data)