Investigation of the mode of inheritance of insulin-dependent diabetes mellitus in Japanese subjects.

Abstract

Previous studies have shown that insulin-dependent diabetes mellitus is positively associated with HLA-DR4 and HLA-DR9 in Japanese populations. It was proposed that susceptibility to the disease is determined by a single HLA allele associated with both DR4 and DR9. DR genotypes in a Japanese population with insulin-dependent diabetes mellitus were determined by DRB/DQB RFLP analysis. A single disease-susceptibility-allele model was tested by the antigen-genotype-frequency-among-patients method. Recessive and additive inheritance of a single susceptibility allele were rejected. The DR9-associated disease-susceptibility allele in Japanese subjects is distinct from both the DR3- and DR4-associated susceptibility alleles in white Caucasians. The data suggest further complexity in the inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus.

• Authors: D Jenkins, M A Penny, Y Uchigata, K H Jacobs, C H Mijovic, Y Hirata, T Otani, J Fletcher, A R Bradwell, A H Barnett
• Journal: American journal of human genetics (Am J Hum Genet) Vol. 50 Issue 5 Pg. 1018-21 (May 1992) ISSN: 0002-9297 [Print] United States
• PMID: 1349195 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-DQ Antigens
• HLA-DR Antigens
• HLA-DR Serological Subtypes
• HLA-DR4 Antigen
• HLA-DR9 antigen

Topics

• Adult
• Alleles
• Asian People (genetics)
• Diabetes Mellitus, Type 1 (genetics)
• Disease Susceptibility
• Female
• Gene Frequency
• HLA-DQ Antigens (genetics)
• HLA-DR Antigens (genetics)
• HLA-DR Serological Subtypes
• HLA-DR4 Antigen (genetics)
• Humans
• Polymorphism, Restriction Fragment Length