Alterations in acetyl coenzyme A carboxylase activities in voles and mice treated with monosodium aspartate.

Abstract

Changes of body weights and hepatic acetyl-CoA carboxylase activities were measured in voles and mice treated with monosodium-L-aspartate (MSA). MSA was administrated subcutaneously to neonates at 4 mg/g. The MSA-treated mice showed remarkable obesity, associated with the increase in the plasma insulin concentrations and acetyl-CoA carboxylase activities. The activity of acetyl-CoA carboxylase of control voles was very low; under half that of mice. In the MSA-treated voles, although the plasma insulin concentrations also increased, acetyl-CoA carboxylase activities were not elevated and signs of obesity were not observed.

• Authors: T Arai, M Sasaki, M Shiomi, T Nonaka, K Ochiai, Y Oki
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 54 Issue 1 Pg. 131-5 (Feb 1992) ISSN: 0916-7250 [Print] Japan
• PMID: 1348428 (Publication Type: Journal Article)

Chemical References

• Blood Glucose
• Insulin
• Aspartic Acid
• Acetyl-CoA Carboxylase

Topics

• Acetyl-CoA Carboxylase (drug effects)
• Age Factors
• Animals
• Animals, Newborn
• Arvicolinae (metabolism)
• Aspartic Acid (pharmacology)
• Blood Glucose (analysis)
• Body Weight (drug effects)
• Eating (drug effects)
• Female
• Insulin (blood)
• Liver (drug effects, enzymology)
• Male
• Mice
• Mice, Inbred C57BL (metabolism)